Douglas "Doogie" Howser, boy genius, kisses his first girl and loses his first patient, all on the same night 24:22 minutes.
Doogie must rush his girlfriend Wanda to the hospital for an emergency appendectomy when she suddenly becomes ill after their date at a drive-in.
Overtired and under a great deal of stress at work, Doogie is approached by a pair of doctors from another hospital who make him a very enticing job offer.
Doogie throws a wild party when his parents leave town, and soon finds that his irresponsible behavior comes with a price.
After an argument with his parents about purchasing a new car, Doogie moves out of the house, only to find that trying to live on his own at 16 is not as easy as he imagines.
Much to Doogie's dissatisfaction, Vinnie makes a video documentary about the boy genius for a class project.
Doogie and Wanda break up, and Doogie learns that it is not just roses and poems, but compromise and forgiveness, that are the keys to maintaining a relationship.
Vinnie has a blind date with Wanda's obese cousin, Yvette, and gets along surprisingly well with her, while Doogie is bothered by a woman obsessed with plastic surgery.
Doogie reluctantly accompanies his father on their annual fishing trip and learns a lesson from the experience.
Doogie and Wanda decide that they should take the big step in their relationship and have sex, but have second thoughts when a baby is abandoned at the Howsers' doorstep by an unwed mother.
Angry and frustrated over Eastman's refusal to admit sick homeless people, Doogie decides to operate on an injured dog in the hospital because its owner, a little boy, cannot afford a veterinarian.
Doogie feigns an illness on Christmas Eve to attend a party, but he returns to the hospital to assist his overworked colleagues.
Doogie competes in a TV game show for geniuses with prizes worth $100,000, and his friends and family begin dividing up his prizes before the contest is even over.
Wanda becomes jealous when one of Doogie's beautiful patients flirts with him. Mrs. Howser reveals that one of her husband's colleagues made a pass at her.
When a mammogram reveals a benign mass in her breast, Mrs. Howser determines to live her life to the fullest, which includes performing live at a local nightclub.
Doogie is sent to high school to teach safe sex and ends up in a fight with one of the class bullies.
Carmine Delpino pressures his son Vinnie to take over the family business when he discovers he may not have long to live.
In an attempt to impress his new hip friends, Doogie "borrows" his father's BMW. But when the car is towed, it is Vinnie who comes to the rescue.
Doogie and Vinnie become hostages when a young black gang member attempts to rob the store where Vinnie works.
Dr. Howser, despondent that the six-year study he has completed is strikingly similar to one already published, decides to retire from his practice.
Vinnie falls for - and hits it off with - a pretty blind girl whom Doogie is treating. But when her eyesight is restored, the girl is no longer attracted to him.
Doogie and McGuire engage in fierce competition for the "Resident of the Year" award when they become the two top contenders.
Doogie and Wanda cannot find any excitement in their relationship and try to find the source of the problem. Meanwhile, McGuire and Spaulding finally get together for a date and really hit it off.
Doogie gets a date with a Laker Girl, but discovers it is not a match made in heaven. He cannot stop thinking about Wanda.
When Vinnie plans to lose his virginity with Janie, he comes down with a case of tonsillitis. Doogie is jealous when he finds that Wanda is going to France for the summer to live with a French student's family.
Doogie is haunted by a Frankenstein-like dream and, with the help of a psychologist, realizes that he has been neglecting his own life so he can attend to his medical duties.
Doogie is surprised by a visit from Raymond Alexander, the newly rehabilitated gang member who once held him hostage in a robbery. Doogie invites him home for dinner and gets him a job at the hospital.
Vinnie is failing French class and soon finds himself trapped in an elevator with his pregnant French teacher... who suddenly goes into labor.
Doogie tapes public service health spots for a television music channel and becomes a media sensation overnight.
Doogie admits a homeless man into the hospital who turns out to be legendary blues singer, Blind Otis Lemon.
Doogie is faced with having to create a fictional illness for a rich hypochondriac who makes large contributions to the hospital when she is cured of her ills. Vinnie decides to drop out of high school.
Vinnie is making a slasher film and Doogie is given the responsibility of deciding if a 13-year-old genius is a suitable candidate for medical school.
Doogie is jealous when Wanda becomes enamored with the nude male model in her life drawing class. A pretty young model with an eating disorder is admitted into the hospital. Doogie is asked to participate in the hospital's annual bachelor auction.
Janine tells Vinnie that her parents have offered to buy her a car if she breaks up with him, and she is considering it. Mrs. Howser's parents visit for Thanksgiving, reigniting an old battle between her father and Dr. Howser.
Spaulding strikes up a romance with Dr. Canfield, and Doogie is excited to be among the few doctors chosen to work with a renowned reconstructive surgeon.
Vinnie is looking for someone to write a recommendation letter for his application to N.Y.U. Film School. Coincidentally, the head of ABC-TV programming has just been admitted to the hospital.
Doogie is attracted to Lisa, a nursing student at the hospital, and asks her out on a date without telling Wanda. A patient who checks into the hospital has two wives, each unknown to the other.
Doogie and Vinnie are faced with a dilemma: Do they tell Dr. Howser that Vinnie had an accident with Doogie's car?
Plans for the class formal are dashed when Wanda's mother is killed in an automobile accident.
Doogie reluctantly agrees to play in the big championship basketball game with St. Michael's Hospital, despite the fact that he is far from an athlete.
The hospital's board of directors is very pleased with the mural project it has instituted at the medical center for children patients -- until it is discovered that the artist has AIDS.
Vinnie manages to convince Doogie and Dr. Howser to take him along on their annual father-son vacation.
Mrs. Howser's parents, Don and Irene, drop by for a surprise visit while the Howsers are having their kitchen remodeled. Don promptly offends the contractor, who quits on the spot.
Dealing with the loss of her mother, Wanda no longer has time to go out with Doogie. So he asks a student nurse to attend the hospital's Monte Carlo Night with him.
Mrs. Howser gets a job as a patient advocate at the hospital, and Doogie and his father have mixed feelings about it.
McGuire resigns from Eastman and joins the Physicians Flying Service, where he feels his work will be of greater importance. Meanwhile, Doogie is frantic to find a date for the annual hospital dance when Michele dumps him.
Vinnie is nervous about being accepted to film school. Doogie is excited that the Hollisters are finally having a baby.
Vinnie cheats on Janine. Janine winds up in a passionate kiss with Doogie. Raymond meets his estranged father at the hospital.
Vinnie and Janine convince Doogie to ask Wanda to the prom. Doogie is impressed by a young girl with a strong will to live who is awaiting a heart transplant.
Doogie and Vinnie move out of their parent’s homes and share their own apartment, but they are soon on each other’s nerves.
Doogie decides to give up the new apartment, just as the Howsers try to adopt to the “Empty Nest Syndrome”.
Because her parents will not let Janine date Vinnie, she decides they should elope.
A girl in Vinnie’s film class comes on strong to him. Meanwhile, Janine confesses to Vinnie that she is not a virgin.
Doogie is excited to find that Wanda is coming home from school for an art show, but is devastated when he sees her there with another boy.
Doogie and Vinnie argue about a Civil War screenplay they are writing. Doogie and Dr. Howser argue over their respective tactics of dealing with patients.
Vinnie convinces Doogie to drive to Chicago and surprise Wanda for her birthday. But the '57 Chevy overheats in the desert, stranding them.
Doogie is miffed when his parents ask him to contribute to room and board. An intern at the hospital grows squeamish at the sight of blood.
Doogie and Wanda have a fight on the phone. Vinnie and Janine are not seeing eye to eye either.
Doogie has his eyes on Cecilia, the hospital librarian, but is put off by the size of her nose.
Doogie is upset when Vinnie spends time with his pretentious film school buddies analyzing the art of Jerry Lewis films.
Mrs. Howser reunites with her old college boyfriend, Wally “Howlin’ Wolf” Goldstein, before their twentieth college reunion.
Vinnie becomes nervous when Doogie tells him that he will be examining a 3,000-year-old mummy at the hospital.
After arguing about how tough their respective days were, Vinnie bets Doogie that the he would not last a weekend working with him at Burger Baby.
The star of television’s “L.A. Med” observes Doogie at the hospital to give his character more dimension.
Doogie discovers that the woman whom he has been dating for two months has a four-year-old son she has not told him about.
A self-confident, patronizing medical student gets on Doogie's nerves. Doogie and Spaulding share an intimate moment and he wonders what it means.
Confused about what area of medicine to specialize in, Doogie decides he would like to go into practice with his father.
Janine’s parents think she is going to college every day, but in reality, she has dropped out and is working in a department store.
When Vinnie discovers that Janine is enjoying herself alone during spring break in Palm Springs; he drags Doogie along to confront her.
Wanda returns home from school and is unhappy that her father has a new girlfriend. Vinnie is upset over the fact that he is short.
Doogie and Dr. Howser decide to perform medical work in the poor villages of Honduras for their annual father-son vacation.
Doogie recounts his experiences—both professional and personal—during the Los Angeles riots.
Mrs. Howser is shocked to find Doogie and her boss, Suzanne Rogers, skinny dipping in the back yard pool.
When Doogie and Vinnie are robbed at gunpoint, Doogie decides to buy a gun for protection.
Doogie decides to move out of his parents’ home. Vinnie tells the Howsers that his parents are getting divorced.
At Canfield’s request, Doogie becomes a patient at the hospital and is forced to share a room wit Elena Spencer. Vinnie becomes smitten with a bride-to-be.
Doogie suffers from nightmares after he makes an error during an operation. Vinnie wrestles with the responsibility of voting in the elections.
Doogie is incredulous when a cute student nurse finds Vinnie more desirable than himself. Raymond passes his exam as an emergency technician, but still feels inferior to his fellow workers
Doogie challenges a young deaf woman who is given the chance of having her hearing partially restored. Vinnie must produce a student film, but is daunted by its minuscule budget.
Vinnie becomes perplexed when Janine attempts to reestablish their relationship. Doogie must decide if a patient should lose his high status as a heart-transplant recipient when he catches the man smoking.
As Thanksgiving approaches, Vinnie suffers from insomnia brought on by stress. Doogie fears that he is becoming a workaholic.
Doogie and his father clash over the diagnosis of a young boy who may or may not have been the victim of child abuse.
Mrs. Howser substitutes for her ailing husband on Doogie’s annual father-son fishing trip.
Doogie allows a gorgeous model to move in with him after she produces another lease to the loft.
Doogie receives a taste of his own medicine after he lies to his colleagues that he made love to Michele. Vinnie is shocked when he discovers that his new roommate is gay.
David Howser considers accepting the position as Head of Family Medicine at the hospital. Vinnie is stunned when his father begins dating another woman.
Doogie fantasizes he is Sherlock Holmes when Michele dates another man. Spaulding announces her engagement.
Vinnie and Laura make love… but Laura begins to suspect that Vinnie may have lost more than just his virginity. Doogie treats a famous actress for a mysterious illness.
Doogie meets a former baby-sitter whom he has not seen since childhood—but is still just as beautiful. Vinnie tries to get a Hollywood director to read his script.
Vinnie withdraws 16,000 dollars from his bank when a computer makes an accounting error. A young patient develops a crush on Doogie.
Doogie becomes the focus of a series of caricatures drawn by a newspaper cartoonist who is diagnosed with cancer.
Vinnie is selected as a jurist in an assault case. Doogie is shocked to discover that a respected doctor at the hospital is a fake.
Vinnie convinces Doogie to enroll in an acting class. Enlightened by the experience, Doogie decides he has been on the fast tract too long, and decides to resign from Eastman and travel abroad.